facebook pixeldeprexis® | The Digital Depression Therapy Program
Skip to content (Press Enter)
Get 30% off deprexis® Learn More

Create a path forward with an online therapy proven to help with depression

deprexis® is a web-based software for depression that uses proven techniques, similar to what you’d experience with your healthcare provider.1
an illustrated woman's profile houses the events of her day, from joining friends to playing instruments

deprexis® is tailored to you

deprexis® is an online digital therapy that can help you move forward in your own way. deprexis® uses cognitive behavioral therapy (CBT)–based techniques and artificial intelligence (AI)–guided technology to tailor what you see based on your responses regarding your symptoms and challenges with depression.1-4

What makes deprexis® stand out?

deprexis® offers the flexibility to fit with any existing treatment plan1,6,11,12
Illustration of people walking on a path

deprexis® is proven to help1

Short term

In a clinical study, people who added deprexis® to their care plan saw a significant improvement in their depression symptoms.1

People who added deprexis® to their care plan were 12x more likely to see an improvement in symptoms compared with people who did not add deprexis® to their care plan.1*

*An improvement was defined as a 50% reduction in self-reported symptoms of depression between when deprexis® was started and at the end of the study.

Long term
In another clinical study, patients who added deprexis® to their care plan were still benefiting 6 months after therapy ended.10
deprexis® users highly recommend the program

In a clinical study where patients self-reported depression symptom severity improvement, nearly 85% of people who used deprexis® said they would recommend it to a friend.2

In a recent survey, nearly 18 million adults in the United States reported having depression15

If you're feeling depressed, you are not alone.

Nearly 80% of people with depression say they experience challenges related to work, home, or social activities because of their depression. See how deprexis® can work to help you take on depression.16
Learn More
Abstract flowers
  • 1. Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
  • 2. Meyer B, Bierbrodt J, Schroder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Intervent. 2015;2(1):48-59.
  • 3. Driessen E, Hollon SD. Cognitive behavioral therapy for mood disorders: efficacy, moderators and mediators. Psychiatr Clin North Am. 2010;33(3):537-555.
  • 4. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed March 11, 2021. https://apa.org/ptsd-guideline/patients-andfamilies/cognitive-behavioral.pdf
  • 5. Meyer B, Berger T, Caspar F, et al. Effectiveness of a novel integrative online treatment for depression (deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15.
  • 6. Berger T, Hammerli K, Gubser N, et al. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266.
  • 7. Moritz S, Schilling L, Hauschildt M, et al. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521.
  • 8. Schroder J, Bruckner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076.
  • 9. Fischer A, Schroder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223.
  • 10. Klein JP, Berger T, Schroder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228.
  • 11. Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455-462.
  • 12. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychother Psychosom. 2017;86(6):341-350.
  • 13. Bucker L, Bierbrodt J, Hand I, et al. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859.
  • 14. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed March 11, 2021. https://orexo.com/investors/regulatory-press-releases/2020-05-11-orexo-acquiresexclusive-us-rights-to-commercialize-deprexis-a-world-leading-digital-therapy-to-helppatients-manage-the-symptoms-of-depression
  • 15. Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health  (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://www.samhsa.gov/data/
  • 16. Brody DJ, Pratt LA, Hughes JP. Prevalence of depression among adults aged 20 and over: United States, 2013-2016. NCHS Data Brief, no 303. Hyattsville, MD: National Center for Health Statistics. 2018.

deprexis® is not a healthcare provider and does not provide medical advice, diagnosis, or standalone treatment. If you need immediate medical attention, please contact your healthcare provider or go to the closest emergency room.