Illustration of person with long hair on their phone

Experience the power of digital depression therapy

deprexis is one of the most researched digital therapies in the world that uses proven techniques to help individuals with mild-to-severe depression

Digital therapy that feels personal

deprexis was designed with individual needs in mind. Everyone is different, and that idea is at the core of how deprexis works. As people interact with the program, their sessions are uniquely customized based on their input. This isn't a one-size-fits-all therapy…it’s truly personal.

Chatting icon

Driven by individual input

Consistent interaction is at the core of every deprexis experience

Therapist with patient icon

Guided by cognitive behavioral therapy

Digitally integrates an evidence-based approach to alleviate negative thought and behavior patterns

Growth chart icon

Grows with you

Learns from information you share to provide a customized experience that evolves over the three month duration of therapy

Clock icon

24/7 access

100% cloud-based ensures discretion and confidentiality for all deprexis users

Looking for access to deprexis? Find out how, and get important updates by checking the box and signing up below.

deprexis can help

Illustration of person sitting at desk
Developed by experts

Created by a team of clinical psychologists, psychotherapists, and software developers to optimize every aspect of the deprexis experience

Illustration of person leaving a birdcage

Real-world proof

Studied in over 2,800 people across 11 clinical trials in multiple clinical scenarios

deprexis is a web application indicated for the adjunctive treatment of chronic or recurrent depression or depressive disorders as a primary or secondary diagnosis (e.g. as a comorbidity in multiple sclerosis or epilepsy) for patients 18 years of age or older who are experiencing a depressive episode.

Be a part of the experience

Whether you're looking to use, order, or provide deprexis, email us at or call us at 1-833-DEPREXIS for more information that's tailored to your needs


1. Meyer B, Berger T, Caspar F, Beevers CG, Andersson G, Weiss M. Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2): e15. Published 2009 May 11. doi:10.2196/jmir.1151   2. Berger T, Hämmerli K, Gubser N, Andersson G, Caspar F. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266. doi:10.1080/16506073.2011.616531   3. Moritz S, Schilling L, Hauschildt M, Schröder J, Treszl A. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521. doi:10.1016/j.brat.2012.04.006   4. Schröder J, Brückner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076. doi:10.1111/epi.12833   5. Meyer B, Bierbrodt J, Schröder J et al. Effects of an Internet intervention (Deprexis) on severe depression symptoms: Randomized controlled trial. Internet Intervent. 2015;2(1):48-59.   6. Fischer A, Schröder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223. doi:10.1016/S2215-0366(14)00049-2   7. Klein JP, Berger T, Schröder J, et al. Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychother Psychosom. 2016;85(4):218-228. Hidoi:10.1159/000445355   8. Berger T. Evaluating an e-mental health program ("deprexis") as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord, 2017; vol. 227, pp. 455-462   9. Beevers C. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol, 2017; vol. 85, pp. 1-14   10. Zwerenz R. Improving the Course of Depressive Symptoms After Inpatient Psychotherapy Using Adjunct Web-Based Self-Help: Follow-Up Results of a Randomized Controlled Trial. J Med Internet Res. 2019;21(10): e13655. doi:10.2196/13655   11. Bücker L, Bierbrodt J, Hand I, Wittekind C, Moritz S. Effects of a depression-focused internet intervention in slot machine gamblers: A randomized controlled trial [published correction appears in PLoS One. 2018 Aug 23;13(8):e0203145]. PLoS One. 2018;13(6):e0198859. Published 2018 Jun 8. doi:10.1371/journal.pone.0198859