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Experience the power of digital depression therapy

deprexis® is one of the most researched digital therapies in the world1-11 that utilizes cognitive behavioral therapy (CBT) techniques, a proven approach to help individuals with depression.12

Digital therapy that feels personal

deprexis® was designed with individual needs in mind. Everyone is different, and that idea is at the core of how deprexis® works. As people interact with the program, their sessions are uniquely customized based on their input. This isn't a one-size-fits-all therapy…it’s truly personal.3

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Driven by individual input

Personalized interaction is at the core of every deprexis® experience.

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Guided by CBT techniques

Digitally integrates an approach that has been proven in clinical studies to alleviate negative thought and behavior patterns.12

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Grows with you

Learns from information you share to provide a customized experience that evolves over the 3-month duration of therapy.

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24/7 access

100% cloud-based ensures discretion and confidentiality for all deprexis® users.

deprexis® can help

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Developed by experts

Created by a team of clinical psychologists, psychotherapists, and software developers to optimize every aspect of the deprexis® experience. Together, they've developed a technology that delivers an exclusive digital therapy experience.13

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Real-world proof

Studied in over 2800 people across 11 clinical trials.1-11 A clinical study showed that nearly 80% of people using deprexis® were satisfied with their experience.3

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How it works

deprexis® responds to your input to create meaningful interactions that can help you move forward in your own way.

Your journey starts here

Whether you’re in an ongoing quest for new therapies or just starting out, deprexis® is the support system that meets you where you are.

There when you need us

Our team is always here to answer any questions regarding access to deprexis®, coverage information, or technical support.

deprexis is a web application indicated for the adjunctive treatment of chronic or recurrent depression or depressive disorders as a primary or secondary diagnosis (eg, as a comorbidity in multiple sclerosis or epilepsy) for patients 18 years of age or older who are
experiencing a depressive episode.


1. Meyer B, Bierbrodt J, Schröder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: Randomized controlled trial. Internet Interventions. 2015;2(1):48-59. doi:10.1016/j.invent.2014.12.003. 2. Beevers CG, Pearson R, Hoffman JS, Foulser AA, Shumake J, Meyer B. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380. doi:10.1037/ccp0000171. 3. Meyer B, Berger T, Caspar F, Beevers CG, Andersson G, Weiss M. Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15. doi:10.2196/jmir.1151. 4. Berger T, Hämmerli K, Gubser N, Andersson G, Caspar F. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266. doi:10.1080/16506073.2011.616531. 5. Moritz S, Schilling L, Hauschildt M, Schröder J, Treszl A. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521. doi:10.1016/j.brat.2012.04.006. 6. Schröder J, Brückner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076. doi:10.1111/epi.12833. 7. Fischer A, Schröder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223. doi:10.1016/S2215-0366(14)00049-2. 8. Klein JP, Berger T, Schröder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228. doi:10.1159/000445355. 9. Berger T. Evaluating an e-mental health program ("deprexis") as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2017;227:455-462. 10. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychotherapy and Psychosomatics. 2017; 86(6):341-350. 11. Bücker L, Bierbrodt J, Hand I, Wittekind C, Moritz S. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859. doi:10.1371/journal.pone.0198859. 12. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed June 9, 2020. 13. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed October 30, 2020.