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Create a path forward with an online therapy proven to help with depression

deprexis® is a 12-week online program that can help people create more positive thoughts and behaviors. It uses proven counseling techniques like what you might get from a therapist or other healthcare provider, without having to connect with a live person.1,3-5
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Responsive to you

Available 24/7 and accessible when you need it most, deprexis® personalizes its tools and resources to you. It's clinically proven to help people feel less depressed when added to their current treatment.1-14

a man looking at his ipad with deprexis app opened

This is an actual interaction from within the program.

Discover the deprexis® experience

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deprexis® could be the option for you


deprexis® asks questions and uses your answers to customize strategies that can help you with depression.

Clinically proven

deprexis® is one of the most researched digital therapies, proven to help reduce depression in 2800+ patients across 11 clinical trials.1-2,5,7-14

Uses trusted techniques

deprexis® uses proven cognitive behavioral therapy (CBT)–based techniques and more to help you create positive thought patterns.3,5

Always available

deprexis® is accessible when you need it. Sign in with an internet-connected smartphone, computer, or tablet.6
deprexis® is a proven complement to other depression therapies.1,2

$399 for the deprexis® experience


The 3-month deprexis® program includes:

  • 12 weeks of tailored cognitive behavioral therapy–based content that can help you manage depression long after the program is completed1-2,5,7-14
  • 24/7 access across connected phones, tablets, and computers6
  • Behavioral modification tips5
  • Biweekly patient health questionnaire (ie, PHQ-9) analysis5
  • Guided meditations and mindfulness exercises3,5
  • Downloadable worksheets and summaries for later use5
  • Full program available in 9 languages15

deprexis® Testimonials

*Participants received complimentary access to deprexis® for their testimonials.

Have questions
about deprexis®?
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Clinically proven to help1

Short term

People who added deprexis® to other treatments being used were 12x more likely to see an improvement in symptoms* compared with people who did not add deprexis® to their current treatment.1

*An improvement was defined as a 50% reduction in self-reported symptoms of depression between when deprexis® was started and at the end of the study.

Long term

In a clinical study, people felt less depressed up to 3 months after completing the program.

deprexis® users highly recommend the program

In a clinical study where patients self-reported depression symptom severity improvement, nearly 80% of people who used deprexis® said they would recommend it to a friend.2

  • 1. Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
  • 2. Meyer B, Berger T, Caspar F, et al. Effectiveness of a novel integrative online treatment for depression (deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15.
  • 3. Driessen E, Hollon SD. Cognitive behavioral therapy for mood disorders: efficacy, moderators and mediators. Psychiatr Clin North Am. 2010;33(3):537-555.
  • 4. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed March 11, 2021. https://apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral.pdf
  • 5. Meyer B, Bierbrodt J, Schröder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Intervent. 2015;2(1):48-59.
  • 6. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed March 11, 2021. https://orexo.com/investors/regulatory-press-releases/2020-05-11-orexo-acquires-exclusive-us-rights-to-commercialize-deprexis-a-world-leading-digital-therapy-to-help-patients-manage-the-symptoms-of-depression
  • 7. Berger T, Hämmerli K, Gubser N, et al. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266.
  • 8. Moritz S, Schilling L, Hauschildt M, et al. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521.
  • 9. Schröder J, Brückner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076.
  • 10. Fischer A, Schröder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223.
  • 11. Klein JP, Berger T, Schröder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228.
  • 12. Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455-462.
  • 13. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychother Psychosom. 2017;86(6):341-350.
  • 14. Bücker L, Bierbrodt J, Hand I, et al. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859.
  • 15. Deprexis launches in Brazil. News release. Orexo AB (publ.). April 13, 2018. Accessed December 10, 2021. https://gaia-group.com/en/news/deprexis-launches-in-Brazil.html

deprexis® is not a healthcare provider and does not provide medical advice, diagnosis, or standalone treatment. If you need immediate medical attention, please contact your healthcare provider or go to the closest emergency room.