Digital Therapy That Works. deprexis is clinically proven to significantly reduce depressive symptoms.

deprexis® is a 12-week online program that can help people create more positive thoughts and behaviors. It uses proven counseling techniques like what you might get from a therapist or other healthcare provider, without having to connect with a live person.1, 3-5



What is deprexis?

deprexis is an online program designed for people with depression, tailored to meet your individual needs. Through a virtual dialogue, it offers suggestions, methods, and techniques to help you manage negative thoughts and foster positive emotions, guiding you on your journey back to life.

How does deprexis work?

deprexis engages you in a conversations and tailors responses based on your answers. The goal of deprexis is to help you build the coping skills you need to make progress with your depression.

It empowers you to help yourself through features like inspiring audio sessions that you can listen to anytime, even on the go. A mood diary helps track your progress. deprexis fits with any existing treatment plan. It does not require medical supervision and is not intended to replace medical treatment.

$399 for the deprexis® experience - this is what you can expect:

12 weeks of tailored cognitive behavioral therapy–based content that can help you manage depression long after the program is completed.1-2,5,7-14

Guided meditations and mindfulness exercises.3,5

Biweekly patient health questionnaire (ie, PHQ-9) analysis.5

Data security. You can use deprexis anonymously by registering with pseudonymized data that cannot reveal your identity. Your information is 100% confidential and never shared.

Downloadable worksheets and summaries for later use.5

24/7 access across internet-connected phones, tablets, and computers.6

deprexis works

deprexis is developed by GAIA AG, the global leader in the field of Digital Therapeutics. It has already helped many patients worldwide.1-15 Its effectiveness has been confirmed in 11 studies conducted by renowned doctors and therapists, including Dr. Christopher G Beevers from the University of Texas, Austin. No other online program has provided this level of evidence of effectiveness worldwide.

GET ACCESS

Are you interested?

If you would like more information about deprexis or wish to purchase it for $399, simply fill out the form below – free of charge and without obligation – and we will provide you with further details.

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GET ACCESS AND MORE INFORMATION

deprexis consists of 10 sequential sessions, resembling the process of psychotherapy but in a digital format. Instead of interacting with a therapist, users engage with the program. It begins by providing information about depression, followed by guidance to identify negative thought and behavior patterns and gradually build positive activities.

After completing the sessions, users can access summaries, worksheets, and audio materials for the remainder of the usage period (at least 3 months) for review and reinforcement as needed.


deprexis is available for $399, providing 90 days of access. After submitting the form, we will contact you with further details. If you decide to purchase, we will issue an invoice. Upon payment, you will receive an activation code, which you can redeem to begin your access. The 90-day period starts upon entering the activation code.


Our studies and extensive experience show that deprexis is safe, with no known serious side effects. For more information, please refer to the deprexis user manual.


You can use deprexis on your smartphone, tablet, or computer with an internet connection. No special technical skills are required. Anyone who can read text and input information can use the program.


Do you have any questions or need additional information?

Send us an email at: info@deprexis.com

Intended Purpose

deprexis is a web application indicated for the adjunctive treatment of chronic or recurrent depression or depressive disorders as a primary or secondary diagnosis (e.g. as a comorbidity in multiple sclerosis or epilepsy) for patients 18 years of age or older who are experiencing a depressive episode. 

deprexis as an interactive online program can be accessed via any internet access. In order to use deprexis, the patient will receive an access key. This access key entitles the patient to use deprexis for 90 days after the first registration.

deprexis is not intended to replace or discourage seeking treatment from a health care professional.

1. Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
2. Meyer B, Berger T, Caspar F, et al. Effectiveness of a novel integrative online treatment for depression (deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15.
3. Driessen E, Hollon SD. Cognitive behavioral therapy for mood disorders: efficacy, moderators and mediators. Psychiatr Clin North Am. 2010;33(3):537-555.
4. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed March 11, 2021. https://apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral.pdf
5. Meyer B, Bierbrodt J, Schröder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Intervent. 2015;2(1):48-59.
6. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed March 11, 2021. https://orexo.com/investors/regulatory-press-releases/2020-05-11-orexo-acquires-exclusive-us-rights-to-commercialize-deprexis-a-world-leading-digital-therapy-to-help-patients-manage-the-symptoms-of-depression
7. Berger T, Hämmerli K, Gubser N, et al. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266.
8. Moritz S, Schilling L, Hauschildt M, et al. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521.
9. Schröder J, Brückner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076.
10. Fischer A, Schröder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223.
11. Klein JP, Berger T, Schröder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228.
12. Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455-462.
13. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychother Psychosom. 2017;86(6):341-350.
14. Bücker L, Bierbrodt J, Hand I, et al. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859.
15. Deprexis launches in Brazil. News release. Orexo AB (publ.). April 13, 2018. Accessed December 10, 2021. https://gaia-group.com/en/news/deprexis-launches-in-Brazil.html