facebook pixeldeprexis® | The Digital Depression Therapy Program
Get 30% off deprexis® Learn More
Create a path forward with an online therapy proven to help with depression1
deprexis® is a web-based software for depression that uses proven techniques, similar to what you’d experience with your healthcare provider.1
Silhouette Illustration
deprexis® is
tailored to you
deprexis® is an online digital therapy that can help you move forward in your own way. deprexis® uses cognitive behavioral therapy (CBT)–based techniques and artificial intelligence (AI)–guided technology to tailor what you see based on your responses regarding your symptoms and challenges with depression.1-4
What makes deprexis® stand out?
deprexis® offers the flexibility to fit with any existing treatment plan1,6,11,12
Illustration of people walking on a path
deprexis® is
proven to help1
Short term
In a clinical study, people who added deprexis® to their care plan saw a significant improvement in their depression symptoms.1
People who added deprexis® to their care plan were 12x more likely to see an improvement in symptoms compared with people who did not add deprexis® to their care plan.1*
*An improvement was defined as a 50% reduction in self-reported symptoms of depression between when deprexis® was started and at the end of the study.
Long term
In another clinical study, patients who added deprexis® to their care plan were still benefiting 6 months after therapy ended.10
deprexis® users highly recommend the program
In a clinical study where patients self-reported depression symptom severity improvement, nearly 85% of people who used deprexis® said they would recommend it to a friend.2
In a recent survey, nearly 18 million adults in the United States reported having depression15
If you're feeling depressed, you are not alone.
Nearly 80% of people with depression say they experience challenges related to work, home, or social activities because of their depression. See how deprexis® can work to help you take on depression.16
Learn More
Abstract flowers
  • 1. Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (deprexis) for depression in a United States adult sample: a parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
  • 2. Meyer B, Bierbrodt J, Schroder J, et al. Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Intervent. 2015;2(1):48-59.
  • 3. Driessen E, Hollon SD. Cognitive behavioral therapy for mood disorders: efficacy, moderators and mediators. Psychiatr Clin North Am. 2010;33(3):537-555.
  • 4. American Psychological Association. What is cognitive behavioral therapy? Clinical practice guideline for the treatment of posttraumatic stress disorder. July 2017. Accessed March 11, 2021. https://apa.org/ptsd-guideline/patients-andfamilies/cognitive-behavioral.pdf
  • 5. Meyer B, Berger T, Caspar F, et al. Effectiveness of a novel integrative online treatment for depression (deprexis): randomized controlled trial. J Med Internet Res. 2009;11(2):e15.
  • 6. Berger T, Hammerli K, Gubser N, et al. Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn Behav Ther. 2011;40(4):251-266.
  • 7. Moritz S, Schilling L, Hauschildt M, et al. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012;50(7-8):513-521.
  • 8. Schroder J, Bruckner K, Fischer A, et al. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014;55(12):2069-2076.
  • 9. Fischer A, Schroder J, Vettorazzi E, et al. An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry. 2015;2(3):217-223.
  • 10. Klein JP, Berger T, Schroder J, et al. Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother Psychosom. 2016;85(4):218-228.
  • 11. Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455-462.
  • 12. Zwerenz R, Becker J, Knickenberg RJ, et al. Online self-help as an add-on to inpatient psychotherapy: efficacy of a new blended treatment approach. Psychother Psychosom. 2017;86(6):341-350.
  • 13. Bucker L, Bierbrodt J, Hand I, et al. Effects of a depression-focused internet intervention in slot machine gamblers: a randomized controlled trial [published correction appears in PLoS One. Aug 23, 2018;13(8):e0203145]. PLoS One. 2018;13(6):e0198859.
  • 14. Orexo acquires exclusive US rights to commercialize deprexis®, a world-leading digital therapy to help patients manage the symptoms of depression. News release. Orexo AB (publ.). May 11, 2020. Accessed March 11, 2021. https://orexo.com/investors/regulatory-press-releases/2020-05-11-orexo-acquiresexclusive-us-rights-to-commercialize-deprexis-a-world-leading-digital-therapy-to-helppatients-manage-the-symptoms-of-depression
  • 15. Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health  (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://www.samhsa.gov/data/
  • 16. Brody DJ, Pratt LA, Hughes JP. Prevalence of depression among adults aged 20 and over: United States, 2013-2016. NCHS Data Brief, no 303. Hyattsville, MD: National Center for Health Statistics. 2018.